Cytoskeletal dysregulation underlies Buruli ulcer formation

Public release date: 15-Mar-2013
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Mycobacterium ulcerans infects the skin and subcutaneous tissues and secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers. In this issue of the Journal of Clinical Investigation, researchers led by Caroline Demangel at the Pasteur Institue in Paris investigated the molecular actions of mycolactone and found that it dysregulates the cellular skeleton (cytoskeleton) through activation of a protein known as N-WASP. They found that excessive N-WASP activity caused defects in cell adhesion and migration that impaired the integrity of the skin. Demangel and colleagues demonstrated that they could block the degradation process by administration of the N-WASP inhibitor wiskostatin. These results reveal the molecular pathogenesis of M. ulcerans and suggest that drugs that disrupt mycolactone/N-WASP interaction could be used to treat Buruli ulcers.

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TITLE:

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

AUTHOR CONTACT:

Caroline Demangel
Institut Pasteur, Paris Cedex 15, FRA
Phone: 33-1-40-61-30-66; E-mail: demangel@pasteur.fr

View this article at: http://www.jci.org/articles/view/66576?key=27d03cca761796d4a69e

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Public release date: 15-Mar-2013
[ | E-mail | Share ]

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Mycobacterium ulcerans infects the skin and subcutaneous tissues and secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers. In this issue of the Journal of Clinical Investigation, researchers led by Caroline Demangel at the Pasteur Institue in Paris investigated the molecular actions of mycolactone and found that it dysregulates the cellular skeleton (cytoskeleton) through activation of a protein known as N-WASP. They found that excessive N-WASP activity caused defects in cell adhesion and migration that impaired the integrity of the skin. Demangel and colleagues demonstrated that they could block the degradation process by administration of the N-WASP inhibitor wiskostatin. These results reveal the molecular pathogenesis of M. ulcerans and suggest that drugs that disrupt mycolactone/N-WASP interaction could be used to treat Buruli ulcers.

###

TITLE:

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

AUTHOR CONTACT:

Caroline Demangel
Institut Pasteur, Paris Cedex 15, FRA
Phone: 33-1-40-61-30-66; E-mail: demangel@pasteur.fr

View this article at: http://www.jci.org/articles/view/66576?key=27d03cca761796d4a69e

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-03/joci-cdu030813.php

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